Neisseria Gonorrhoeae Disease

Neisseria gonorrhoeae (Gonococci)

Neisseria gonorrhoeae

Neisseria gonorrhoeae

Neisseria gonorrhoeae is a venereal disease

1. Morphological characters

  • They are gram negative,non-sporeforming diplococci with concave adjacent side.
  • It appear like a shape of a kidney.
  • It contains pili that provide adhesion to mucosal surface and inhibit phagocytosis.

2. Cultural characters

  • These gonococci cells grow aerobically as well as anaerobically.
  • These organism can grow on selective media like Chocolate agar, Mueller-Hinton and Thayer Martin medium.
  • The optimum temperature for its growth is 36° C and it reguires a pH range of 7.2 to 7.6.
  • After incubation the colonies appear small, convex and translucent.

3. Biochemical reactions

  • This Neisseria strain shows catalase and oxidase test positive.
  • It has the ability to ferment glucose by producing acid and no gas.
  • It does not ferment maltose, sucrose, and lactose.

4.Resistance

  • This organism is a pure human parasite it cannot survive outside the human body.
  • Outside the human body it get killed in two hours.
  • It is very sensitive to heat, drying and antiseptics.

5. Pathogenecity

  • The disease spreads through sexual contact.
  • In men diseases starts with acute urethritis and spreads from urethra to prostate,seminal vesicle and epididymis.
  • In women disease starts with urethra and cervix uteri and may extend to Bartholin’s gland, Fallopian tube and endometrium.

6. Laboratory diagnosis

  • The sample such as urethral discharge, cervical swaps is collected.
  • Observation of Gram negative diplococci provide presumptive evidence of Gonorrhae by smear examination and it is unreliable in women.

7. Treatment

  • The strains were first sensitive to Sulphonamide  and Penicillin but further these strains developed drug resistance against these drugs.
  • The drugs like Ceftriaxone, Ciprofloxacin, Olfoxacin, Doxycyclin or Erythromycin are the drugs of choice.

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